Monday, May 6, 2019
16:30 – 18:30
Registration/Information
17:30 – 19:30
Welcome Reception
Tuesday, May 7, 2019
8:00 – 18:00
Registration/Information
8:30 – 8:40
Morten Gram Pedersen, University of Padova, Italy
Opening Remarks
Session I: Exocytosis I
Sebastian Barg, Uppsala University, Chair
8:40 – 9:10
Arun Anantharam, University of Michigan, USA
Synaptotagmin-7 Endows a Population of Chromaffin Granules with Distinct Calcium Sensing and Fusion Properties
9:10 – 9:40
Ben O'Shaughnessy, Columbia University, USA
Coarse-Grained Mathematical Modeling of Neurotransmitter Release
9:40 – 10:00
Yongli Zhang, Yale University, USA*
Sec1/Munc18 Proteins Catalyze SNARE Assembly by Templating SNARE Folding and Association
10:00 – 10:20
Alex Kreutzberger, University of Virginia, USA*
Reconstitution of Regulated Exocytosis of Different Secretory Vesicle Types
10:20 – 10:50
Coffee Break
Session II: Systems
Dinah Loerke, University of Denver, USA, Chair
10:50 – 11:20
Jens Rettig, Saarland University, Germany
Molecular Insights Into Exo- and Endocytosis of Cytotoxic Granules
11:20 – 11:50
Tomas Kirchhausen, Harvard University, USA
Imaging Subcellular Dynamics from Molecules to Multicellular Organisms
11:50 – 12:10
Belinda Akpa, North Carolina State University, USA*
Multiscale Modeling of Plant Vacuole Fusion in Guard Cells: Positioning HOPS as the Key Regulator of Stoma Morphology
12:10 – 13:10
Lunch
Session III: Fusion Pore I
Jakob B. Sørensen, University of Copenhagen, Denmark, Chair
13:10 – 13:40
Patrik Rorsman, OCDEM, United Kingdom
Insulin Exocytosis: Normal Physiology and Disruption in Type-2 Diabetes
13:40 – 14:10
Uri Ashery, Tel-Aviv University, Ramat Aviv, Israel
Fusion Pore Constriction Controls the Dynamics of Vesicular Content Release
14:10 – 14:30
Agata Witkowska, Max Planck Institute for Biophysical Chemistry, Germany*
Insights on SNARE-Mediated Fusion Learned From Early Membrane Fusion Intermediates
14:30 – 16:00
Break/Poster Session I
Session IV: Curvature
Jenny Hinshaw, NIH, USA, Chair
16:00 – 16:30
Michelle Knowles, University of Denver, USA
Protein Regulation of Exosome Secretion
16:30 – 17:00
Ravi Radhakrishnan, University of Pennsylvania, USA
Biophysics of Membrane Curvature Remodeling at Molecular and Mesoscopic Length Scales
17:00 – 17:30
Mohsen Sadeghi, Freie Universität Berlin, Germany
Parametric Particle-Based Model for Large-Scale Simulations of Membrane Dynamics
17:30 – 17:50
Comert Kural, The Ohio State University, USA*
Curvature Generation by Endocytic Clathrin Coats
18:00 – 19:30
Tour of the Botanical Garden
Dinner on own
Wednesday, May 8, 2019
8:45 – 11:00
Tour of the Historical University
Lunch on own
12:30 – 19:00
Registration/Information
Session V: Fission
Jenny Hinshaw, NIH, USA, Chair
13:00 – 13:30
Thomas Pucadyil, Indian Institute of Science Education and Research, India
ATP-Dependent Membrane Remodeling Links EHD1 Functions to Endocytic Recycling
13:30 – 14:00
Patricia Bassereau, Institut Curie, France
ESCRT-III Filaments Have Opposite Curvature-Related Orientations on Membranes
14:00 – 14:30
Jeanne Stachowiak, University of Texas at Austin, USA
Intrinsically Disordered Proteins as Physical Drivers of Membrane Fission
14:30 – 14:50
Henry Nguyen, University of California, San Francisco, USA*
Cryo-EM Structures Reveal Progressive Membrane Constriction by the ESCRT-III Proteins IST1 and CHMP1B
14:50 – 16:20
Break/Poster Session II
Session VI: Synapses
Morten Gram Pedersen, University of Padova, Italy, Chair
16:30 – 17:00
Takeshi Sakaba, Doshisha University, Japan
Comparison of the Transmitter Release Properties Between the Calyx of Held Synapse and Mossy Fiber-CA3 Synapse
17:00 – 17:30
Alexander Walter, Leibniz-Institut für Molekulare Pharmkologie (FMP), Germany
Release Site Recruitment and Activation as Mechanisms of Presynaptic Plasticity
17:30 – 18:00
Stephanie Gupton, University of North Carolina at Chapel Hill, USA
An Unbiased Classification Approach Reveals Multiple Fusion Categories of VAMP2-Mediated Exocytosis
18:00 – 18:15
Break
Session VII: Superresolution
Dinah Loerke, University of Denver, USA, Chair
18:15 – 18:45
Susan Cox, King's College London, United Kingdom
Faster and Better: Taking Localization Microscopy Into Live Cells
18:45 – 19:15
Katharina Gaus, University of New South Wales, Australia
Single Molecule Localization Microscopy of Receptor Signaling
Dinner on own
Thursday, May 9, 2019
Session VII: Fusion Pore II
Sebastian Barg, Uppsala University, Sweden, Chair
8:00 – 19:00
Registration/Information
8:30 – 9:00
Ling-Gang Wu, NINDS, NIH, USA
Visualizing Membrane Structural Remodeling During Fusion and Fission in Live Cells
9:00 – 9:30
Manfred Lindau, Cornell University, USA
The Structure of the Fusion Pore
9:30 – 9:50
Raya Sorkin, Vrije Univit Amsterdam, Netherlands*
Membrane Binding, Bending, and Remodeling by Synaptotagmin-1 and Doc2b
9:50 – 10:10
Rafael Lira, Max Planck Institute, Germany*
How and How Much Has it Fused? Detecting Fusion Intermediates and Quantifying Fusion Efficiency
10:10 – 10:40
Coffee Break
Session IX: Exocytosis II
Jakob B. Sørensen, University of Copenhagen, Denmark, Chair
10:40 – 11:10
Frederic Meunier, Queensland Brain Institute, Australia
Need for Speed: Dynamic Nanoclustering and Unclustering of Munc18/Syntaxin-1 During Exocytosis
11:10 – 11:40
Giuliana Cortese, University of Padova, Italy
Advanced Statistics for Spatio-Temporal Events of Exocytosis
11:40 – 12:00
Nikhil Gandasi, Uppsala University, Sweden*
Birth of a Nanodomain: Vesicle Docking is Initiated by Rab3 Positive Vesicles Identifying Rim Sties to Tether at the Plasma Membrane
12:00 – 13:00
Lunch
Session X: Fusion Proteins
Morten Gram Pedersen, University of Padova, Italy, Chair
13:00 – 13:30
Laura Endter, University of Göttingen, Germany
Molecular Simulations of Protein-Mediated Membrane Remodeling
13:30 – 13:50
Pavel Jungwirth, IOCB Prague, Czech Academy of Sciences, Czech Republic*
Cell Penetration and Membrane Fusion: Two Sides of the Same Coin
13:50 – 14:10
Mahmoud Moradi, University of Arkansas, USA*
Influenza Hemagglutinin-Mediated Membrane Fusion: An All-Atom Molecular Dynamics Study
14:10 – 14:30
James Munro, Tufts Unversity, USA*
Conformational Dynamics Related to Membrane Fusion Observed in Single Viral Envelope Glycoproteins
14:30 – 16:00
Break/Poster Session III
Session XI: Neuronal Endocytosis
Sebastian Barg, Uppsala University, Chair
16:00 – 16:30
Jürgen Klingauf, University of Münster, Germany
Visualizing Compensatory Endocytosis Dynamics in 'Xenapses,' TIRFM-Amendable Synapses
16:30 – 17:00
Ira Milosevic, European Neuroscience Institute Göttingen, Germany
Novel Functions of Endophilins-A in Exocytosis and Membrane Trafficking
17:00 – 17:15
Break
Keynote Lecture
Jakob B. Sørensen, University of Copenhagen, Denmark, Chair
17:15 – 18:00
Axel Brunger, Stanford University, USA
Molecular Mechanisms of Synaptic Neuronal Exocytosis
19:00
Banquet
Friday, May 10, 2019
8:00 – 12:30
Registration/Information
Session XII: Mitochondrial Fusion and Fission
Jenny Hinshaw, NIH, USA, Chair
8:30 – 9:00
Karin Busch, University of Münster, Germany
Mitochondrial Membrane Dynamics Versus Steady Compartmentalization: A Contradiction? What Superresolution Imaging Can Tell Us
9:00 – 9:30
Luca Scorrano, University of Padova, Italy
Consequences of Mitochondrial Fusion Changes
9:30 – 9:50
Dora Mahecic, EPFL Institute of Physics, Switzerland*
Membrane Bending Energy and Tension Govern Mitochondrial Division
9:50 – 10:10
Katja Faelber, Max Delbrück Center, Germany*
Structural Insights Into Mitochondrial Inner Membrane Remodeling
10:10 – 10:40
Coffee Break
Session XIII: Exocytosis III
Jakob B. Sørensen, University of Copenhagen, Denmark, Chair
10:40– 11:10
Fernando Marengo, University of Buenos Aires, Argentina
Endocytosis and Vesicle Replenishment After the Exocytosis of the Immediately Releasable Pool in Mouse Chromaffin Cells
11:10 – 11:40
Aleksandra Radenovic, École Polytechnique Fédérale de Lausanne, Switzerland
The Power of Correlative Superresolution Imaging
11:40 – 12:00
Francesco Montefusco, University of Padova, Italy*
How is Granule Release Affected by Location and Number of Different Types of Ca2+ Channels? Markov Chain Models Provide Analytic Results
12:00 – 12:15
Closing Remarks and Biophysical Journal Poster Awards Presentation
Morten Gram Pedersen, University of Italy, Padova, Italy
Lunch on own
*Short talks selected from among submitted abstracts