Sunday, September 24, 2023
5:00 PM - 8:45 PM
Registration
7:00 PM - 7:10 PM
Welcome and Opening Remarks
Ling-Gang Wu, NIH, USA
Session I: Keynotes I
Ling-Gang Wu, NIH, NINDS, USA, Chair
7:10 PM - 7:35 PM
John Heuser, Washington University in St. Louis, USA
Revisiting Electron Microscopy's "Golden Decade" of Imaging Synaptic Vesicle Dynamics: The 1970's
7:35 PM - 8:00 PM
Edwin Chapman, University of Wisconsin-Madison, USA
Unexpected Interplay Between Two Presynaptic Calcium Sensors
8:00 PM - 8:45 PM
James Rothman, Yale University, USA
Turbo-Charging Synaptic Vesicles for Explosive Release of Neurotransmitters
Monday, September 25, 2023
7:30 AM - 8:30 AM
Breakfast
8:00 AM - 5:00 PM
Registration
Session II: Dense Core Vesicle Fusion and Fission
Volker Kiessling, University of Virginia, USA, Chair
8:30 AM - 8:55 AM
Erdem Karatekin, Yale University, USA
Membrane Fusion and Fission: Lessons from Unexpected Places
8:55 AM - 9:10 AM
Kobina Essandoh, University of Michigan, USA*
Molecular Regulation of Atrial Natriueretic Peptide Secretion in Cardiomyocytes by the RAB3GAP1 and GTPASE Cycle
9:10 AM - 9:35 AM
Arun Anantharam, The University of Toledo, USA
Signaling Networks Coupling Calcium to Secretion in the Adrenal Medulla
9:35 AM - 10:00 AM
Ira Milosevic, Oxford University, United Kingdom
Negative Regulation of Exocytosis by Amisyn
10:00 AM - 10:30 AM
Break
Session III: Intra/Inter-Cellular Fusion and Fission
TBD, Chair
10:30 AM - 10:55 AM
Aurelian Roux, University of Geneva, Switzerland
Reconstituting ESCRT-III Mediated Membrane Fission In Vitro
10:55 AM - 11:20 AM
Sandy Maday, University of Pennsylvania, USA
Autophagy-Lyosomal Pathways in Neurons and Astrocytes
11:20 AM - 11:45 AM
Michael Kozlov, Tel Aviv University, Israel
Model for Ring Collapse and Membrane Fission in ER Tubular Networks
11:45 AM - 12:00 PM
Lisa Redlingshofer, Max Planck Institute, Germany*
Reconstructing the Collective Behaviour of the Endosomal Membrane Fusion Machinery
12:00 PM - 12:25 PM
Elizabeth Chen, University of Texas, Southwestern Medical Center, USA
Function of ABC G1/G4 Transporters and Cholesterol in Cell-Cell Fusion
12:25 PM - 1:25 PM
Lunch
Session IV: Endocytosis, Membrane Bending and Fission
Sarah Nyenhuis, NIH, USA, Chair
1:35 PM - 2:00 PM
Thomas Pucadyil, Indian Institute of Science and Education and Research, India
Mechanistic Analysis of Membrane Fission and Discovery of Novel Fission Proteins
2:00 PM - 2:25 PM
David Drubin, University of California, Berkeley, USA
Harnessing Actin-Assembly Forces to Drive Vesicle Formations During Clathrin-Mediated Endocytosis
2:25 PM - 2:40 PM
Richard Hooy, University of California, Berkeley, USA*
Self-Assembly and Structure of a Clathrin-Independent AP-1: ARF1 Tubular Membrane Cell
2:40 PM - 3:05 PM
Vadim Frolov, Ikerbasque-Basque Foundation for Science, Spain
Molecular Mechanosensing in Dynamin-Driven Membrane Remodeling
3:15 PM - 4:45 PM
Poster Session I
4:45 PM - 7:30 PM
Free Time/Dinner on Own
Session V: Extracellular and Mitochondrial Vesicles
Prabhodh Abbineni, Loyola University, Chicago, USA, Chair
Chantell Evans, Duke University, USA
Mitochondrial Derived Vesicles: A New Mitochondrial Quality Control Mechanism
7:55 PM - 8:20 PM
Alissa Weaver, Vanderbilt University, USA
Biogenesis of RNA-Containing Extracellular Vesicles at ER-Membrane Contact Sites
8:20 PM - 8:45 PM
Ann Wehman, University of Denver, USA
Extracellular Vesicles Budding and Lipid Asymmetry
8:45 PM - 9:10 PM
Michelle Knowles, University of Denver, USA
Multivesicular Endosome Fusion Kinetics Depend on Exosome Tethering and Temperature
Tuesday, September 26, 2023
7:30 AM - 8:30 AM
Breakfast
8:30 AM - 4:15 PM
Registration
Session VI: Synaptic Vesicle Fusion
Jianyuan Sun, Chinese Academy of Sciences, China, Chair
8:30 AM - 8:55 AM
Ege Kavalali, Vanderbilt University, USA
Functional Nano-Organization of Synapses
8:55 AM - 9:10 AM
Amelia Ralowicz, Dartmouth College, USA*
Spontaneous Synaptic Vesicles Function is Correlated with Number of Vesicles in Readily Releasable Pool
9:10 AM - 9:35 AM
Jeremy Dittman, Cornell University, Weill Medical College, USA
Molecular Insights into Mun13 and Complexin Function at the Synapse
9:35 AM - 10:00 AM
Skyler Jackman, Oregon Health and Science University, USA
High-Affinity Calcium Sensors Mediate Asynchronous Vesicle Fusion
10:00 AM - 10:30 AM
Coffee Break
Session VII: Fusion and Fission in Infection and Disease
Katya Heldwein, Tufts University, USA, Chair
10:30 AM - 10:55 AM
Carol Parent, University of Michigan, USA
The Neutrophil Nucleus as a Signaling Hub during Neutrophil Chemotaxis
10:55 AM - 11:20 AM
Gregory Melikian, Emory University, USA
HIV-1 Preferentially Fuses with PH-Neutral Vesicles in Cell Lines and Primary CD4+ T-Cells
11:20 AM - 11:35 AM
Xin Wang*
Macropinocytosis in Sars CoV2 Infection
11:35 AM - 11:50 AM
Gonzalo Gonzalez-Del Pino, Tufts University, USA*
Structural and Functional Characterization of the Herpes Simplex Virus Membrane Fusion Regulator, GH/GL
11:50 AM - 12:15 PM
Comert Kural, Ohio State University, USA*
Sensitization of Cancer Cells to FAS-Induced Apoptosis Through Endocytosis Inhibition
12:15 PM - 1:15 PM
Lunch
Session VIII: Membrane Bending, Fusion, and Endocytosis
Ioana Butu, Columbia University, USA, Chair
1:25 PM - 1:50 PM
Wenting Zhao, Nanyang Technological University, Singapore
Nanoscale Membrane Topography Engineering: In Cells, Invitro and In Between
1:50 PM - 2:15 PM
Ben O'Shaugnessy, Columbia University, USA
Mechanical Regulation of Membrane Fusion, Exocytosis and Endocytosis Studied by Coarse-Grained
Simulation and Experimental Data Analysis
2:15 PM - 2:30 PM
Aline Tschanz, EMBL, Germany*
Clathrin Coats Partially Preassemble and Subsequently Bend During Endocytosis
2:30 PM - 2:55 PM
Marko Kaksonen, University of Geneva, Switzerland
Evolutionary Cell Biology Approach to Clathrin-Mediated Endocytosis
3:05 PM - 4:35 PM
Poster Session II
4:35 PM - 7:30 PM
Free Time/Dinner on Own
Session IV: Dense Core Vesicle Fusion and Endocytosis
Debasis Das, Tata Institute of Fundamental Research, India, Chair
7:30 PM - 7:55 PM
Ling-Gang Wu, NIH, NINDS, USA
Dynamics of Membrane Fusion and Endocytosis in Secretory Cells
7:55 PM - 8:20PM
Lukas Tamm, University of Virginia, USA
Membrane Lipids Couple Synaptotagmin to SNARE Mediated Granule Fusion in Insulin Secreting Cells
8:20 PM - 8:45 PM
Manfred Lindau, University of Miami, USA
All SNAP25 Copies in the Vesicle-Plasma Membrane Contact Zone Change Conformation During Vesicle Priming
8:.45 PM - 9:10 PM
Corey Smith, Case Western Reserve University, USA
Rapid Electrochemical Measure of Neurotransmitter Dynamics in a Beating Pig Heart
Wednesday, September 27, 2023
7:00 AM - 8:30 AM
Breakfast
8:30 AM - 4:30 PM
Registration
Session X: Endocytosis and Membrane Bending
Jefferson Knight, University of Colorado, USA
8:30 AM - 8:45 AM
Santiago Di Pietro, Colorado State University, USA*
Mechanism of Actin Capping Protein Recruitment and turnover During Clathrin Mediated Endocytosis
8:45 AM - 9:10 AM
Justin Taraska, NIH, USA
Measuring the Nanoscale Structure of Endocytosis with Light and Electron Microscopy
9:10 AM - 9:35 AM
Margaret Johnson, Johns Hopkins University, USA
Membrane Bending and Assembly Costs for Clathrin Coat Formation
9:35 AM - 10:00 AM
Shigeki Watanabe, Johns Hopkins University, USA
Dynamin Prime- Accelerating Endocytosis at Synapses
10:00 AM - 10:30 AM
Coffee Break
Session XI: Synaptic Vesicle Fusion and Endocytosis
Chair: Jiajie Diao, University of Cincinnati, USA
10:30 AM - 10:55 AM
Noa Lipstein-Thoms, Max Planck Institute for Multidisciplinary Sciences, Germany
Human UNC13A Gene Variations Cause a Neurodevelopmental Syndrome and Impair Synaptic Function
10:55 AM - 11:20 AM
Stephanie Gupton, University of North Carolina Chapel Hill, USA
Spatial and Temporal Regulation of Constitutive Exocytosis in Cell Shape Change
11:20 AM - 11:45 AM
Michael Cousin, University of Edinburgh, United Kingdom
Dynamin-1 Dysfunction in Human Disease
11:45 AM - 12:00 PM
Stephane Gasman, Institut des Neurosciences Cellulaire et Integratives, CNRS, France*
Transbilayer Phospholipid Scrambling is Essential for Efficient Synaptic Vesicle Endocytosis
12:00 PM - 1:00 PM
Lunch
Session XII: Fusion Pore and Release Mechanisms
Ronald Holz, University of Michigan, USA
1:10 PM - 1:35 PM
Zhuan Zhou, Peking University, China
Differential Co-Release of Catecholamine and ATP from a Vesicle Fusion Pore in Mouse Adrenal Chromaffin Cells
1:35 PM - 2:00 PM
Joshua Zimmerberg, NIH, USA
Aggregation-Dependent Lipid/Fusion Peptides Pore Formation, and Microvesicles that Secrete Exosomes
2:00 PM - 2:25 PM
Meyer Jackson, University of Wisconsin-Madison, USA
Fusion Pore Dynamics in Endocrine and Synaptic Exocytosis
2:25 PM - 2:50 PM
Sebastian Barg, Uppsala University, Sweden
Fusion Pore Regulation in Insulin-Secreting Beta Cells
3:00 PM - 4:30 PM
Poster Session III
4:30 PM - 5:15 PM
Free Time
Session XIII: Keynotes II
Michelle Knowles, University of Denver, USA
5:15 PM - 5:40 PM
Phyllis Hanson, University of Michigan, USA
Beyond Repair: ESCRT's Enhance Membrane Resilience
5:40 PM - 6:05 PM
Jenny Hinshaw, NIH, USA
Cryo-EM Structures of Dynamin Proteins Involved in Membrane Fission and Fusion
6:05 PM - 6:50 PM
Axel Brunger, Stanford University, USA
Molecular Mechanisms of Calcium-Triggered Exocytosis
6:50 PM - 7:00 PM
Closing Remarks and Biophysical Journal Poster Awards
7:30 PM
Dinner
* Contributed talks selected from among submitted abstracts