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Disulfide Bridge: More Than Just a Simple Bond Disulfide Bridge: More Than Just a Simple Bond

Disulfide Bridge: More Than Just a Simple Bond

Anonym 0 12850

Disulfide bridges, a common type of covalent bond in protein structures, are usually believed to maintain structural stability of proteins, especially small peptides that lack hydrophobic cores.  Our study, in this April 26 issue of Biophysical Journal, revealed that disulfide bridges are also critical, at least in the case of the MCoTI-II peptide, for holding together a native structure that is frustrated. The cover image shows the native structure (left) as well as snapshots from ...

Tags: ProteinsPeptidesBJ cover artBiophysical Journaldisulfide bridgesfolding funnel
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Alzheimer's Biomarker FDDNP Depicted on the BiophysJ Cover

Anonym 1 3625
The latest BiophysJ cover image is based on the article “Molecular Interactions of Alzheimer’s Biomarker FDDNP with Aβ Peptide,” written by Christopher Lockhart and Dmitri K. Klimov. Klimov explains the scientific purpose of the image, as well as the work that went into it, in the blog post below: The cover art represents the molecules of FDDNP biomarker bound to Abeta peptide implicated in Alzheimer's disease. The structure is one of countless conformations generated by replica exchange ...
Tags: biophysicsscienceImagingresearchMolecular Simulationmolecular interactionsPeptides
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SAHELI MITRA:

A must read.

Coronavirus Structure, Vaccine and Therapy Development
Brennan Weaver:

Pretty nice read. I wish I could have written something about Pi. It's my 2nd favorite number value. Also, I don't think Pi is as mysterious as everyone thinks it is. It's just a number with a lot of personalities. And I do believe there is a last digit.

Pi Is Encoded in the Patterns of Life
Harel Weinstein:

Just perused the article "From Dynamics to Membrane Organization- Experimental Breakthroughs Occasion a ‘‘Modeling Manifesto’’ in the August 21 issue. While the Perspective is intriguing, the sheer Chutzpah of writing a "manifesto" about a field of modeling with lists of "demands" based on experiments that in many cases are more limited in scope or reality than any physics-based model, is quite astounding. Neither artificial membrane slabs, nor "live cells" imaged under conditions in which cells have a shabby life that doesn't last long (how much of this is due to the mistreatment of the membrane proteins?) share established behaviors that must be matched or else.... No experiment, computational or using imaging, is meant to mimic reality, only to probe it based on models and assumptions that can be falsified.

As to the role of the cytoskeleton, what does this tell us about the membrane itself, or the behavior of membrane proteins as individual molecules in their interplay with the membrane? And since this unrelated scaffold differs greatly between cells, what is the "correct matching standard"? All models are wrong, some (computational, or on the stage of a microscope) are useful, but in my opinion, self-critical, humble, and rigorous scientific reasoning are preferable to a manifesto in order to foster progress.

In Search of…Protein Interaction Partners
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