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Two days in one post

Anonym 0 3960

Couldn't post yesterday. It was a long day that started with preparing for my poster in the afternoon and ended with actually presenting the poster. This year I was less apprehensive, and had more people speak to me (probably unrelated events). My work is in the area of molecular dynamics simulation of lipid-peptide systems. Got some extremely helpful suggestions from experts in this area, something that shall immensely help my future research. I did manage some time yesterday to check out ...

Tags: careerChitrak Guptaresumecv
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A hectic day

Anonym 0 4135

It has been a long day. Up since 3:45 am (yeah, it isn't a typo). And that is in eastern time. So it has been close to 21 hours since I had a proper sleep (not counting the dozing off on the flight). However, I still didn't arrive at the meeting until about 4:30. Just in time for registration, but too late for most of the excitements of the first day. Except, of  course, the mixer. And the Cryo-EM subgroup session. I was pretty much an outsider in the subgroup: Cryo-EM is not my area of ...

Tags: Chitrak Gupta
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It's time for the BPS meeting!

Anonym 0 3501

It is that time of the year again! I am adding final touches to my poster, rushing to print it off, and creating my itinerary for the BPS meeting. It really feels like last week that we were all in Baltimore for the 59th annual meeting. Last year was my first time at the BPS. For all the first-timers out there, this meeting might be bigger than you think! I was overwhelmed for the first couple of days!  That is partly because at that point I was still not aware of all the wonderful features ...

Tags: Chitrak Gupta
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SAHELI MITRA:

A must read.

Coronavirus Structure, Vaccine and Therapy Development
Brennan Weaver:

Pretty nice read. I wish I could have written something about Pi. It's my 2nd favorite number value. Also, I don't think Pi is as mysterious as everyone thinks it is. It's just a number with a lot of personalities. And I do believe there is a last digit.

Pi Is Encoded in the Patterns of Life
Harel Weinstein:

Just perused the article "From Dynamics to Membrane Organization- Experimental Breakthroughs Occasion a ‘‘Modeling Manifesto’’ in the August 21 issue. While the Perspective is intriguing, the sheer Chutzpah of writing a "manifesto" about a field of modeling with lists of "demands" based on experiments that in many cases are more limited in scope or reality than any physics-based model, is quite astounding. Neither artificial membrane slabs, nor "live cells" imaged under conditions in which cells have a shabby life that doesn't last long (how much of this is due to the mistreatment of the membrane proteins?) share established behaviors that must be matched or else.... No experiment, computational or using imaging, is meant to mimic reality, only to probe it based on models and assumptions that can be falsified.

As to the role of the cytoskeleton, what does this tell us about the membrane itself, or the behavior of membrane proteins as individual molecules in their interplay with the membrane? And since this unrelated scaffold differs greatly between cells, what is the "correct matching standard"? All models are wrong, some (computational, or on the stage of a microscope) are useful, but in my opinion, self-critical, humble, and rigorous scientific reasoning are preferable to a manifesto in order to foster progress.

In Search of…Protein Interaction Partners
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